IgA kappa light and heavy chain deposition disease in multiple myeloma
نویسندگان
چکیده
منابع مشابه
Monitoring IgA multiple myeloma: immunoglobulin heavy/light chain assays.
BACKGROUND The use of electrophoresis to monitor monoclonal immunoglobulins migrating in the β fraction may be difficult because of their comigration with transferrin and complement proteins. METHODS Immunoassays specific for IgGκ, IgGλ, IgAκ, IgAλ, IgMκ, and IgMλ heavy/light chain (HLC) were validated for use in the clinical laboratory. We assessed sample stability, inter- and intraassay var...
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The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were o...
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Multiple myeloma (MM) is a malignant disorder in which plasma cells of a single clone proliferate and accumulate in the bone marrow, leading to bone destruction and bone marrow failure. These abnormal plasma cells secrete monoclonal Ig. It is estimated that 24050 new MM cases will occur in the US in 2014 (1.4% of all new cancer cases), with a median age at diagnosis of 69 years (1 ). The diagno...
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Light and heavy chain deposition disease (LHCDD) is a rare entity with less than two dozen reported cases [1,2]. The term LHCDD was proposed in 1984 as a variant of light chain deposition disease (LCDD), to characterize a subset of patients in whom deposits contain both light and heavy chain antigenic determinants. We present a case of LHCDD in a renal graft and evidence that this process repre...
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Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys. We describe here a 78-year-old woman whose renal biopsy showed nodular glomerulosclerosis, initially diagnosed as diabetic nephropathy. Detailed kidney bio...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2018
ISSN: 0007-1048
DOI: 10.1111/bjh.15420